The New South Wales Cancer, Lifestyle and Evaluation of Risk Study (CLEAR): A resource for cancer research. — ASN Events

The New South Wales Cancer, Lifestyle and Evaluation of Risk Study (CLEAR): A resource for cancer research. (#261)

Freddy Sitas 1 , Visalini Nair-Shalliker 1 , Micheal Revius 1 , Christina Christou 1 , Sarsha Yap 1 , Katie Armstrong 1 , Usha Salagame 1 , Katherine Christian 1 , Andrew Cottrill 2 , Geoff Delaney 3 , Lauren Haydu 4 , Nasreen Kaandan 3 , Tony Sara 5 , John Thompson 4 , Emily Banks 6 , Michael Barton 3 , Karen Canfell 7 , Dianne O'Connell 1
  1. Cancer Council NSW, Woolloomolloo, NSW, Australia
  2. HCF, Sydney
  3. South West Sydney Local Health District, Liverpool
  4. Melanoma Institute Australia, North Sydney
  5. South East Sydney Illawarra Local Health District, Randwick
  6. Australian National University, ACT
  7. University of New South Wales, Sydney

BACKGROUND: The Cancer Council New South Wales’ (NSW) Cancer, Lifestyle and Evaluation of Risk Study (CLEAR) is an ongoing initiative that commenced in 2006. Designed as an all cancer-case-control study, with follow-up potential, it collects lifestyle, demographic and biospecimen information, for release as an open resource for researchers.
METHODS: Participants are recruited from i) hospitals, ii) cancer related databases, and iii) self-referral as a response to widespread promotion. Cases are NSW residents aged 18 years and above, and diagnosed with a first incident cancer within 18 months of enrolment. Controls comprise cancer-free partners of cases, sex matched, post hoc. Study participants complete a questionnaire and provide an optional blood sample, processed and stored at -80°C. Self reported cancer status is verified via annual linkage with the NSW Central Cancer Registry. Future links to other datasets include deaths and hospital admissions.
RESULTS: CLEAR has recruited 8799 participants (6857 cases and 1942 controls: ~20% response rate). , had a Median age of cases and controls is 62 years. The most common cancers were those of the female breast (n=1782), prostate (n=1119), colorectum (n=1268), melanoma (n=609), and lung (n=278). Positive predictive values for self report of each major cancer type are >95%. . As one of several validation steps the risk of lung cancer in current smokers in both men (OR=31.7 95%CI:14.9-67.7) and women (OR=20.9;95%CI:12.0-36.3), after adjusting for age, SES and migrant status; were similar to other contemporary studies from UK and USA.
CONCLUSIONS: CLEAR is a valuable resource for cancer researchers interested in the causes and consequences of a cancer diagnosis. It has the potential to significantly advance our knowledge in the occurrence and outcome of various cancers.